How Stress Impacts the Immune System

Apr 08, 2024
woman with tissue and blanket

Have you ever gotten sick after a stressful event? Or are you always catching the current cold that is going around the office? Or the illnesses your kids bring home from school or daycare? You know your immunity is a bit off (that's why you're sick) but could it be related to stress? 

 That's a  BIG YES! 

It is now believed that the nervous, endocrine, and immune systems are so intimately connected that they should be regarded as a single network rather than as three separate systems - with stress, you affect all three. This area of study is called psychoneuroimmunoendocrinology - that's a mouthful 🤣

The Link Between Stress and Immune Function:

The relationship between stress and the immune system is intricate and bidirectional. Research has shown that chronic stress can dysregulate the immune response, making you more susceptible to infections, illnesses, and autoimmune disorders.

The body's stress response, primarily mediated by the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS), triggers the release of stress hormones and neurotransmitters such as cortisol and adrenaline (epinephrine). While these chemicals are vital for survival in acute stress situations, prolonged elevation can suppress immune function and create a pro-inflammatory environment in the body and increase your risk of chronic disease and activation of latent viruses. 

How? 

  1. Inhibition of Immune Cells: Chronic stress has been found to suppress the activity of immune cells, such as T cells, B cells, and natural killer cells, which play crucial roles in recognizing and eliminating pathogens. Prolonged exposure to stress hormones can impair the production and function of these immune cells, weakening the body's defense mechanisms.

  2. Inflammatory Response: Stress can trigger an inflammatory response in the body, characterized by the release of pro-inflammatory cytokines. While inflammation is a natural part of the immune response, chronic inflammation can contribute to a range of health problems, including autoimmune disorders and chronic diseases. Chronic stress has been linked to prolonged inflammation, further compromising immune function.

  3. Disruption of Immune Signaling: Stress hormones can interfere with the intricate signaling pathways that regulate immune responses. This disruption can impair communication between immune cells, hindering their coordinated efforts to combat pathogens effectively.

  4. Impact on Gut Health: The gut microbiome plays a crucial role in immune function, with a significant portion of immune cells residing in the gut-associated lymphoid tissue (GALT). Chronic stress can disrupt the balance of gut microbiota, leading to dysbiosis and compromising immune function. Additionally, stress-induced changes in gut permeability may allow harmful pathogens to penetrate the intestinal barrier, further exacerbating immune dysfunction.

How to Boost your Immune Function

Chronic stress can weaken immune function, leaving you more susceptible to illnesses and infections. However, there are steps you can take to bolster your body's defenses and counteract the negative effects of stress. 

  1. Prioritize Sleep: Quality sleep is essential for immune health. During sleep, the body repairs and regenerates tissues, while the immune system works to fend off pathogens. Aim for 7-9 hours of uninterrupted sleep each night, and establish a relaxing bedtime routine to promote restful sleep. Avoid screens and stimulating activities before bedtime, and create a comfortable sleep environment free of distractions.

  2. Maintain a Balanced Diet: Nutrition plays a crucial role in supporting immune function. Focus on consuming a diverse range of nutrient-rich foods, including fruits, vegetables, whole grains, lean proteins, and healthy fats. Incorporate immune-boosting foods such as citrus fruits, berries, garlic, ginger, turmeric, and leafy greens into your diet. Stay hydrated by drinking plenty of water throughout the day, and limit the intake of processed foods, sugary snacks, and excessive alcohol.

    I'm talking more about nutrition and stress this week on instagram- come follow me @lolamacleanDNP and check it out!
  3. Stay Active: Regular exercise not only improves physical fitness but also enhances immune function. Aim for at least 30 minutes of moderate-intensity exercise most days of the week. Choose activities you enjoy, whether it's walking, jogging, cycling, yoga, or dancing. Exercise helps reduce stress hormones, promotes circulation, and stimulates the production of immune cells, contributing to overall well-being.

  4. Practice Stress Management: Effective stress management techniques can mitigate the negative impact of stress on the immune system. Incorporate relaxation practices such as deep breathing, meditation, mindfulness, or progressive muscle relaxation into your daily routine. Engage in activities that bring you joy and relaxation, whether it's spending time in nature, practicing hobbies, listening to music, or connecting with loved ones.

  5. Prioritize Mental Health: Caring for your mental and emotional well-being is essential for immune resilience. Seek support from friends, family, or a mental health professional if you're feeling overwhelmed or struggling with stress, anxiety, or depression. Practice self-compassion, positive self-talk, and gratitude to cultivate a resilient mindset and enhance coping mechanisms.

Conclusion

The relationship between stress and the immune system is complex and multifaceted. While acute stress responses are a natural and adaptive part of human physiology, chronic stress can have profound implications for immune function and overall health. Understanding how stress impacts the immune system is essential for developing effective strategies to mitigate its negative effects. Incorporating stress management techniques such as mindfulness, exercise, and social support can help alleviate stress and bolster immune resilience. By prioritizing your mental and emotional well-being, you can better support your body's innate ability to maintain optimal health and immunity.

Need some guidance? Grab a copy of my free stress busting guide here! It walks you through 5 things you can incorporate in your day to day that help you reduce your stress. 

References:

  1. Segerstrom, S. C., & Miller, G. E. (2004). Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychological bulletin, 130(4), 601–630.
  2. Dhabhar, F. S. (2014). Effects of stress on immune function: the good, the bad, and the beautiful. Immunologic research, 58(2-3), 193–210.
  3. Arck, P. C., & Slominski, A. (2009). Theoharides, TC. Neuroimmunology. Stress hormone regulation: biological role and translation into therapy. Annual review of medicine, 61, 81-90.
  4. Mayer, E. A., Knight, R., Mazmanian, S. K., Cryan, J. F., & Tillisch, K. (2014). Gut microbes and the brain: paradigm shift in neuroscience. The Journal of Neuroscience, 34(46), 15490–15496.
 

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